Pay in installments of $30.00 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Oct 28 - Nov 2
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
Invivo Anti-Mouse CD3ε Recombinant mAbProduct Specification Host Rat Antigen CD3 Synonyms T cell surface glycoprotein CD3 epsilon chain; T cell surface antigen T3 Leu 4 epsilon chain; Cd3e Location Cell membrane Accession P22646 Clone Number S 3759 Antibody Type Rat mAb Application FCM, in vitro T cell stimulation activation, in vivo T cell depletion Reactivity Ms Purification Protein G Concentration 5 mg ml Purity >95% (Determined by SDS PAGE) Endotoxin <1EU mg Conjugation Unconjugated
Product Specification
| Host | Rat |
| Antigen | CD3ε |
| Synonyms | T-cell surface glycoprotein CD3 epsilon chain; T-cell surface antigen T3/Leu-4 epsilon chain; Cd3e |
| Location | Cell membrane |
| Accession | P22646 |
| Clone Number | S-3759 |
| Antibody Type | Rat mAb |
| Application | FCM, in vitro T cell stimulation/activation, in vivo T cell depletion |
| Reactivity | Ms |
| Purification | Protein G |
| Concentration | 5 mg/ml |
| Purity | >95% (Determined by SDS-PAGE) |
| Endotoxin | <1EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, containing no preservative |
| Stability & Storage | 2 to 8 °C for 2 weeks under sterile conditions; |
Background
CD3ε protein, also known as CD3E, is a crucial component of the T-cell receptor (TCR) complex, which is essential for T-cell activation and function. It is a single-pass type I membrane glycoprotein that contains one Ig-like domain and one immunoreceptor tyrosine-based activation motif (ITAM) domain. CD3ε, along with CD3γ, CD3δ, and CD3ζ, forms the TCR-CD3 complex, which plays a vital role in coupling antigen recognition to intracellular signal-transduction pathways. This protein is essential for the proper development of T-cells and is involved in the internalization and downregulation of the TCR-CD3 complex on the cell surface. Defects in the CD3ε gene can lead to severe immunodeficiency and have been linked to a susceptibility to type I diabetes in women.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy